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Upon binding to cd20 rituximab mediates b cell lysis.
Rituximab. Rituximab rituxan is a drug used to treat non hodgkins b cell lymphomas chronic lymphocytic leukemia granulomatosis with polyangiitis previously called wegeners granulomatosis microscopic polyangiitis and rheumatoid arthritis. It targets a protein called cd20 on the surface of the leukaemia and lymphoma cells. Rituximab sticks to all the cd20 proteins it finds. Rituxan rituximab is a prescription medicine used to treat adults with.
With the chemotherapy medicines fludarabine and cyclophosphamide. A severe autoimmune reaction that causes blisters and breakdown of the skin and mucous membranes. Rituximab sold under the brand name rituxan among others is a medication used to treat certain autoimmune diseases and types of cancer. Rituximab is a monoclonal antibody that targets the cd20 antigen expressed on the surface of pre b and mature b lymphocytes.
Patients with cancer who take rituximab intravenous may be at a greater risk of getting a severe health problem called tumor lysis syndrome tlsthis may lead to death. Non hodgkins lymphoma or chronic lymphocytic leukemia. Rituximab is approved to be used in adults either alone or with other drugs to treat. B cell non hodgkin lymphoma nhl that is cd20 positive.
Chronic lymphocytic leukemia cll. If you used rituximab intravenous when you were pregnant tell your babys doctor. Symptoms of granulomatosis with polyangiitis are fever joint pain fatigue and sinusitis. See important safety including boxed warnings for more information.
Rituximab is used alone or in combination with other medicines to treat the following conditions in adults. Rituximab is used to treat certain types of cancer such as non hodgkins lymphoma chronic lymphocytic leukemiait works by slowing or stopping the growth of cancer cells. It is used alone in patients with follicular lymphoma or low grade lymphoma that has relapsed or is refractory doesnt respond to treatment. Alone or with other chemotherapy medicines.
Possible mechanisms of cell lysis include complement dependent cytotoxicity cdc. Some brands of. It is used for non hodgkin lymphoma chronic lymphocytic leukemia rheumatoid arthritis granulomatosis with polyangiitis idiopathic thrombocytopenic purpura pemphigus vulgaris myasthenia gravis and epsteinbarr virus positive mucocutaneous ulcers.
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